Cardiovascular disease risk in an urban African population: a cross-sectional analysis on the role of HIV and antiretroviral treatment

Table 3 HIV and ART status on mean (a) CCA intima-media thickness and (b) carotid distensibility

	HIV-negative			HIV-positive
		ART-naïve	p	First-line ART	p	Second-line ART	p
a) HIV and ART status on mean CCA intima-media thickness (n = 534)
Model 1	REF	− 0.015 (− 0.038 to 0.007)	0.178	− 0.001 (− 0.025 to 0.023)	0.239	0.052 (0.033 to 0.071)	< 0.001
Model 2	REF	− 0.010 (− 0.028 to 0.007	0.239	− 0.012 (− 0.031 to 0.006)	0.187	0.000 (− 0.016 to 0.016)	0.963
Model 3	REF	− 0.009 (− 0.027 to 0.008)	0.287	− 0.012 (− 0.030 to 0.007)	0.219	0.002 (− 0.015 to 0.018)	0.854
Model 4^a	REF	− 0.011 (− 0.029 to 0.008)	0.253	− 0.012 (− 0.032 to 0.007)	0.224	− 0.005 (− 0.023 to 0.013)	0.557
b) HIV and ART status on carotid distensibility (10⁻⁶ N⁻¹ m²) (n = 514)
Model 1	REF	1.314 (− 2.707 to 5.335)	0.521	− 1.365 (− 5.641 to 2.911)	0.531	− 4.315 (− 7.745 to − 0.885)	0.014
Model 2	REF	0.675 (− 2.939 to 4.290)	0.714	0.280 (− 3.573 to 4.134)	0.886	2.387 (− 0.916 to 5.690)	0.156
Model 3	REF	0.470 (− 3.165 to 4.104)	0.800	0.107 (− 3.759 to 3.973)	0.957	2.019 (− 1.353 to 5.391)	0.240
Model 4^b	REF	− 1.567 (− 4.891 to 1.757)	0.355	0.268 (− 3.351 to 3.888)	0.884	0.278 (− 3.046 to 3.601)	0.870

β-coefficient with 95% CI
Model 1 unadjusted
Model 2 adjusted for age
Model 3 adjusted for age and sex
Model 4 adjusted for age, sex, systolic blood pressure, body mass index, LDL cholesterol, HDL cholesterol, glucose and current smoking
ART antiretroviral therapy, CCA common carotid artery, CI confidence interval, HIV human immunodeficiency virus, REF reference
^an = 37 (6.9%) participants were excluded from this model due to missing data in one or more covariates
^bn = 35 (6.8%) participants were excluded from this model due to missing data in one or more covariates

ISSN: 1742-4690