Mutations of Glu560 within HIV-1 Envelope Glycoprotein N-terminal heptad repeat region contribute to resistance to peptide inhibitors of virus entry

Table 1 Inhibition by HR1 and HR2 peptide inhibitors and sCD4

Inhibitor selection	Mutants	N36 (μM)		IZN36 (nM)		T20 (nM)		sCD4 (μg/mL)
Inhibitor selection	Mutants	IC₅₀ ± SD	Ratio	IC₅₀ ± SD	Ratio	IC₅₀ ± SD	Ratio	IC₅₀ ± SD	Ratio
N36/IZN36	LAIwt	1.77 ± 0.22	1.00	29.3 ± 8.95	1.00	251.14 ± 59.67	1.00	4.85 ± 0.015	1.00
N36/IZN36	E560K	6.52 ± 0.43	3.68	59.86 ± 12.93	2.04	148.89 ± 58.78	0.60	1.05 ± 0.010	0.21
T20	E560D	2.81 ± 0.55	1.58	23.15 ± 1.24	0.93	135.92 ± 36.69	0.54	1.37 ± 0.10	0.28
T20	E560G	0.55 ± 0.07	0.31	11.22 ± 0.90	0.29	87.66 ± 21.48	0.24	2.98 ± 0.010	0.61

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