Fig. 2

Inhibition of pseudoviruses bearing Envs with E560K/D/G mutations by broad neutralizing antibodies, 2F5 and 4E10. The IC₅₀ values for the 2F5 and 4E10 targeting at MPER of gp41 were determined for pseudoviruses with Envs containing indicated mutations in U87CD4⁺CXCR4⁺ cells, normalized to the IC₅₀ for the wild-type pseudovirus (LAIwt). Averages and SD values (error bars) of at least three independent experiments are shown. The susceptibility and dose-dependent curves of pseudoviruses with indicated mutation to 2F5 (a) and 4E10 (b) are shown. *p < 0.05 compared with LAIwt