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Table 1 Inhibition of replication-competent HIV-1 (NL4-3 backbone)

From: Characterization of resistance to a potent d-peptide HIV entry inhibitor

 

PIE12-trimer (nM)

C37 (nM)

NL4-3 (WT)

1.33 (0.79)

11.2 (4.07)

W1 (resistant pool)

999 (176)

7.62 (2.18)

W2 (resistant pool)

894 (419)

14.9 (1.31)

Q577R

188 (63)

ND

Q577 N

164 (105)

ND

Q577K

128 (59)

ND

  1. Average IC50 values for clonal NL4-3 (WT), PIE12-trimer 320 nM polyclonal resistant pools (W1 and W2), and Q577 point mutations in the NL4-3 background. Values are averages of IC50’s fit from two independent experiments with triplicate measurements. Standard deviations are shown in parentheses
  2. ND not determined
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Retrovirology

ISSN: 1742-4690

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