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Fig. 3 | Retrovirology

Fig. 3

From: Silencers of HTLV-1 and HTLV-2: the pX-encoded latency-maintenance factors

Fig. 3

Functional domains and predicted structures of the antisense-encoded HTLV-1 HBZ and HTLV-2 APH-2 proteins. The predicted structures were generated using the I-TASSER algorithm and modeled using UCSF-Chimera. a Diagram and structure of the HTLV-1 HBZ-SP1 (spliced-1) isoform. The amphipathic helical motifs (1 and 2) which bind the KIX domains of p300/CBP are indicated. AD, activation domain; NES, nuclear export signal; NLS, nuclear localization signal. b The core IXXL and terminal LXXL modulatory sequences of the HTLV-2 APH-2 protein are indicated in the diagram. nc bZIP nonconventional basic domain/leucine zipper region, NFAR NF90/NF110-binding Nuclear factors associated with double-stranded RNA proteins NF90/NF110-binding region, PLMnb-localization PML nuclear body-localization/APH-2 stabilization domain. The basic regions in HBZ and APH-2 are represented by blue boxes with +++

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