Fig. 2
From: Silencers of HTLV-1 and HTLV-2: the pX-encoded latency-maintenance factors
Functional domains and predicted structures of the HTLV-1 Tax-1 and HTLV-2B Tax-2 transactivator proteins. The predicted structures were generated using the I-TASSER computer algorithm (https://zhanglab.ccmb.med.umich.edu) and modeled using UCSF-Chimera. a Diagram of the HTLV-1 Tax protein and its functional domains. NLS nuclear localization signal, NES nuclear export sequence, ZF zinc finger motif, LZ leucine zipper region. The sites of the M22 (dimerization), G148 V (NF-κB transactivation), and M47 (activation domain) mutations are indicated. b The HTLV-2 Tax-2B protein and its conserved functional domains are shown. The unique C-terminal aa residues 331–356 are not present within the HTLV-1 Tax protein. NLD nuclear localization determinant