Fig. 2

Both resting and activated T cells are sensitive to NNRTI-induced killing. a, b Comparison of resting T cells treated or not with IL-7 (a) and anti-CD3/CD28 activated T cells (infected 2 days after activation) (b). At 5 dpi (resting) or 2 dpi (activated) cells were treated or not with RPV, NVP and or IDV (1 μM each) and stained 4 h (activated) and 24 h (resting and activated) later, with annexin V and anti-HSA antibody. Data indicate Annexin V labeling in pre-gated HSA+ and HSA− fractions. Data are averages and SD of 3 donors and representative of 2 independent experiments. (*p = 0.0006: p-value was calculated with an unpaired two-tailed t-test)