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Table 4 Chemokine genes differentially induced by Tax-A and Tax-B

From: Distinct gene expression signatures induced by viral transactivators of different HTLV-1 subgroups that confer a different risk of HAM/TSP

 

Fold change

Tax-A

Tax-B

Tax A/B ratio

Gene name

Partner (receptor or ligand)

References

Chemokine

90.9

62.4

1.5

CXCL10

CXCR3

[32, 45, 46]

21.8

11.4

1.9

CXCL9

CXCR3

[32, 46]

N.D.a

2.4

 

CCL22

CCR4

[47]

21.2

10.6

2.0

CCL1

CCR8

[29, 48]

N.D.

2.9

 

CCL5

CCR1, CCR3, CCR5

[49, 50]

5.8

2.3

2.5

CCL20

CCR6

[51]

9.0

6.0

1.5

XCL1

XCR1

[52]

Chemokine receptor

5.6

3.8

1.5

CXCR6

CXCL16

None reported

2.2

2.2

1.0

CCR7

CCL19, CCL21

[53]

1.5

N.D.

 

CCRL2/CCR11

CCL2, CCL5, CCL7, CCL8

None reported

  1. aNot detected
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Retrovirology

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