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Fig. 3 | Retrovirology

Fig. 3

From: Distinct gene expression signatures induced by viral transactivators of different HTLV-1 subgroups that confer a different risk of HAM/TSP

Fig. 3

Validation of differentially expressed genes identified by microarray using qRT-PCR in PBMCs of HAM/TSP patients with HTLV-1 subgroup (a) or (b). To confirm whether the obtained in vitro gene expression profiles have clinical significance, we performed real-time qRT-PCR on PBMCs of 37 patients with HAM/TSP (19 subgroup-A and 18 subgroup-B), 20 HCs, and 20 NCs. Among identified Tax-responsive genes, we measured the expression levels of CXCL10 mRNA levels. a The expression levels of CXCL10 in HAM/TSP patients with subgroup-A was significantly higher than in HAM/TSP patients with subgroup-B (p = 0.0334 by Scheffe’s post hoc multiple comparisons test). b There was no significant difference in HTLV-1 PVL between HAM/TSP patients with subgroup-A or -B

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Retrovirology

ISSN: 1742-4690

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