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Table 1 Selection of recent protection/treatment studies using bnAbs

From: The expanding array of HIV broadly neutralizing antibodies

BnAb delivery

Epitope

System

References

Adeno-associated virus (AAV) vectored PGT121

High mannose patch

Humanized mice

[118]

Passive infusion of 3BNC117 and 10-1074

CD4bs

High mannose patch

Non-human primates

[121]

Passive infusion of a Tri-specific mix

CD4bs

MPER

Apex

Non-human primates

[125]

Passive infusion of VRC01

CD4bs

Humans (phase I)

[126]

Passive infusion of VRC01

CD4bs

Humans phase 1

[127]

Passive infusion of VRC01

CD4bs

Humans phase 1

[119]

Passive infusion of 3BNC117

CD4bs

Humans phase 2a

[128]

Passive infusion of 3BNC117 and 10-1074

CD4bs

High mannose patch

Humans phase 1b

[120]