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Fig. 8 | Retrovirology

Fig. 8

From: RNA-induced epigenetic silencing inhibits HIV-1 reactivation from latency

Fig. 8

Impact of shRNAs on maintenance of HeK27me3 and RNA Pol II Phosphorylation, during HIV-1 latency. “In-between” cell lines multiple comparisons were used to determine significant differences between the % Input of a H3K4me3 (left panel) and H3K27me3 (middle panel), or b Phosphorylation of RNA Pol II at pSer2 (left panel) and pSer5 (middle panel), against the levels of Parental (dark-grey). Right panels correspond to “in-within” multiple comparisons between activation (H3K4me3, green) or repression (H3K27me3, red), top-panel; or between elongation (pSer2, green) or stalling (pSer5, red) of RNA Pol II, bottom panel. Data show Mean ± SD (n = 4) from 2 independent ChIP assays. Significance levels are as follows: * = p values from 0.05 to 0.01, ** = p values from 0.009 to 0.001, *** = p values from 0.0009 to 0.0001 and **** = p values < 0.0001

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