Fig. 1
From: Stabilizing HIV-1 envelope glycoprotein trimers to induce neutralizing antibodies
Amino acid substitutions that help stabilize soluble native-like trimers. Crystal structure of the BG505 SOSIP.664 trimer (5CEZ; [7]) displaying amino acid substitutions that stabilize native-like soluble trimers (see text for details). Two protomers are colored in white and one protomer is colored according to different regions. In gp120: V1V2 in cyan, V3 in magenta, inner domain layer 1 in blue, layer 2 in yellow, layer 3 in orange, N- and C-termini in green. Gp41 is colored in red. Boxes show detailed views of regions of the Env trimer that contain stabilizing amino acid substitutions. The substitutions were modeled by using the mutagenesis tool in Pymol molecular graphics system version 2.0.6 [102]