Fig. 1
From: Development of broadly neutralizing antibodies in HIV-1 infected elite neutralizers
Reproduced with permission from [21]
Identification of HIV-1 elite neutralizers and epitope mapping. Typically, plasma samples collected from HIV-1 infected individuals are tested for neutralization against panels of global env-pseudotyped viruses. Volunteers are ranked based on a their neutralization breadth and potency. The broad neutralizing activity in the top neutralizers is then mapped for epitope specificity using mutant viruses, and peptide and protein adsorptions.