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Table 4 Characterization of LTR binding sites critical for 3q12.3 and 11p15.4 promoter activity in tumorigenic cells

From: Promoter expression of HERV-K (HML-2) provirus-derived sequences is related to LTR sequence variation and polymorphic transcription factor binding sites

Provirus

Binding site

LTR

Binding site allele frequency

Binding site evolution

3q12.3

HOX-PBX

5′ LTR

99.68% (fixed)

Acquired

RFX3

5′ and 3′ LTR

99.96% (fixed)

Present at the time of insertion

11p15.4

ATF

5′ LTR

99.88% (fixed)

Acquired

RORA

5′ LTR

50.76% (polymorphic)

Acquired