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Table 4 Characterization of LTR binding sites critical for 3q12.3 and 11p15.4 promoter activity in tumorigenic cells

From: Promoter expression of HERV-K (HML-2) provirus-derived sequences is related to LTR sequence variation and polymorphic transcription factor binding sites

Provirus Binding site LTR Binding site allele frequency Binding site evolution
3q12.3 HOX-PBX 5′ LTR 99.68% (fixed) Acquired
RFX3 5′ and 3′ LTR 99.96% (fixed) Present at the time of insertion
11p15.4 ATF 5′ LTR 99.88% (fixed) Acquired
RORA 5′ LTR 50.76% (polymorphic) Acquired