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Table 3 Unique transcription factor binding sites found in HML-2 5′ LTRs of interest

From: Promoter expression of HERV-K (HML-2) provirus-derived sequences is related to LTR sequence variation and polymorphic transcription factor binding sites

Provirus Unique binding site
1q22 NBRE
3q12.3 CDE, E2F, HOX-PBX, MRG1, PROX1, RFX3, SF1, SOX10, TAL1-E2A, TBX20, TEF-HLF, TGIF, TR2
3q21.2 GLI1, IK3, NFY, NKX29, SIX2, STAT5
5p13.3 CARF, MYBL1
7p22.1b EKLF, GAGA, GLI3
8p23.1c AML1, BHLHB2, DMRT7, HMGA, HOX1-3, MAFF, MEF2, NRF1, PAX1, SOX17, STAT5A
11p15.4 AHRARNT, ATF, ATF6, CETS1P54, EN2, ETS1, FOXP2, FREAC2, HDBP1-2, HHEX, HIVEP1, IRF5, MIF1, NRL, PEGASUS, RORA, SGN1, STAT3, TEF, TGIF2LX
21q21.1 CHOP, NFKAPPAB50, USF, ZNF300
22q11.21 GRHL1, MASH1, TAL1BETAHEB
  1. Only sites unique to each 5′ LTR, as compared to the other eight 5′ LTRs, are shown
  2. Present only in other HML-2 solo LTR(s)
  3. Present in other HML-2 full length provirus(es) and solo LTR(s)