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Table 3 Unique transcription factor binding sites found in HML-2 5′ LTRs of interest

From: Promoter expression of HERV-K (HML-2) provirus-derived sequences is related to LTR sequence variation and polymorphic transcription factor binding sites

Provirus

Unique binding site

1q22

NBRE‡

3q12.3

CDE, E2F, HOX-PBX, MRG1‡, PROX1, RFX3†, SF1†, SOX10, TAL1-E2A, TBX20, TEF-HLF‡, TGIF†, TR2‡

3q21.2

GLI1†, IK3, NFY‡, NKX29†, SIX2‡, STAT5

5p13.3

CARF‡, MYBL1‡

7p22.1b

EKLF‡, GAGA‡, GLI3‡

8p23.1c

AML1‡, BHLHB2‡, DMRT7‡, HMGA‡, HOX1-3‡, MAFF‡, MEF2‡, NRF1‡, PAX1‡, SOX17‡, STAT5A‡

11p15.4

AHRARNT‡, ATF, ATF6, CETS1P54, EN2‡, ETS1, FOXP2†, FREAC2‡, HDBP1-2, HHEX, HIVEP1†, IRF5, MIF1†, NRL, PEGASUS, RORA, SGN1, STAT3, TEF†, TGIF2LX

21q21.1

CHOP†, NFKAPPAB50†, USF†, ZNF300†

22q11.21

GRHL1‡, MASH1†, TAL1BETAHEB†

  1. Only sites unique to each 5′ LTR, as compared to the other eight 5′ LTRs, are shown
  2. †Present only in other HML-2 solo LTR(s)
  3. ‡Present in other HML-2 full length provirus(es) and solo LTR(s)