Promoter expression of HERV-K (HML-2) provirus-derived sequences is related to LTR sequence variation and polymorphic transcription factor binding sites

Table 3 Unique transcription factor binding sites found in HML-2 5′ LTRs of interest

Provirus	Unique binding site
1q22	NBRE^‡
3q12.3	CDE, E2F, HOX-PBX, MRG1^‡, PROX1, RFX3^†, SF1^†, SOX10, TAL1-E2A, TBX20, TEF-HLF^‡, TGIF^†, TR2^‡
3q21.2	GLI1^†, IK3, NFY^‡, NKX29^†, SIX2^‡, STAT5
5p13.3	CARF^‡, MYBL1^‡
7p22.1b	EKLF^‡, GAGA^‡, GLI3^‡
8p23.1c	AML1^‡, BHLHB2^‡, DMRT7^‡, HMGA^‡, HOX1-3^‡, MAFF^‡, MEF2^‡, NRF1^‡, PAX1^‡, SOX17^‡, STAT5A^‡
11p15.4	AHRARNT^‡, ATF, ATF6, CETS1P54, EN2^‡, ETS1, FOXP2^†, FREAC2^‡, HDBP1-2, HHEX, HIVEP1^†, IRF5, MIF1^†, NRL, PEGASUS, RORA, SGN1, STAT3, TEF^†, TGIF2LX
21q21.1	CHOP^†, NFKAPPAB50^†, USF^†, ZNF300^†
22q11.21	GRHL1^‡, MASH1^†, TAL1BETAHEB^†

Only sites unique to each 5′ LTR, as compared to the other eight 5′ LTRs, are shown
^†Present only in other HML-2 solo LTR(s)
^‡Present in other HML-2 full length provirus(es) and solo LTR(s)

ISSN: 1742-4690