Virus isolate | Subtype | Acquired mutations at final passage (week 46) of selective drug pressurea | Acquired mutations (week 26–40)b | |||
---|---|---|---|---|---|---|
DTG | BIC | CAB | EVG | RAL | ||
14514 | B | R263K | None | None | T66I | – |
10387 | B | None | None | None | T66I | E92Q |
10249 | B | R263K | None | None | E92Q | None |
14624 | B | none | None | H51HY | T66I | T97A, N155H |
14637 | B | R263K | R263K0 | R263K | T66I, E157Q, R263K | N155H |
14947 | B | R263K | R263K | R263K, S153A | T66I, E138EK, S147G, Q148R | Y143R, L74M, E92V, F121Y, G163GR |
5326 | B | H51HY | S153Y | L74M, G140S, S147G, Q148K | R263K, S153A | Y143R, L74M, T97A, E157Q |
4742 | C | None | None | R263K | E92EG, R263KR | T66K |
10947 | C | R263K | R263K | S147G | E92V, R263K | – |
6343 | AE | R263K | S153Y | S153Y, G163R | T66I, R263K | – |
14515 | AG | None | R263K | None | T66I, H51HY | – |
96USSN20 | AG | R263K | S153FS, E157EK | L74M, E138K, Q148R, R263K | T66I, Q146R, S147G, Q95R | L74M, V79I, E138K, G140A, Q148R |
-pNL4.3 | B | R263K, M50I | R263K, M50I | S153F | T66I, T97A, S147G, S119R, S153A | T66I, T97A, G163R, D232N |