Broadly neutralizing antibodies: What is needed to move from a rare event in HIV-1 infection to vaccine efficacy?

Subbaraman, Harini; Schanz, Merle; Trkola, Alexandra

doi:10.1186/s12977-018-0433-2

Retrovirology

Table 1 Overview of patient cohort studies investigating viral and disease factors linked with bnAb development

From: Broadly neutralizing antibodies: What is needed to move from a rare event in HIV-1 infection to vaccine efficacy?

Reference	Number of subjects^a	Investigated viral and disease factors	Association with breadth	Additional information on investigated parameter
Doria-Rose et al. [11]	103	Viral load	Positive	Contemporaneous
		Infection duration	None
		Transmission mode	None
		CD4+ T cell levels	None	Contemporaneous
		History of ART use	None
Euler et al. [6]	82	Viral load	Positive	Set point
		CD4+ T cell levels	Negative	Set point
		Disease progression	None
Gray et al. [33]	40	Viral load	Positive	Set point
		CD4+ T cell levels	Negative	6 months post-infection
		CD4+ T cell decline	Positive	Difference between levels pre-infection and at 6 months
Landais et al. [14]	439	Viral load	Positive	Set point
		Infecting subtype	Positive	Subtype C infection
		Infection duration	Positive
		Transmission mode	None
		CD4+ T cell levels	Negative	All tested time points beyond 6 months post-infection
Mikkell et al. [32]	38	Viral load	Positive	Contemporaneous
Piantadosi et al. [48]	70	Viral load	Positive	Set point
		Viral diversity	Positive	Env
		CD4+ T cell levels	None	Contemporaneous
		Disease progression	None
Rusert et al. [12]	4484	Viral load	Positive	Contemporaneous
		Viral diversity	Positive	Pol
		Infecting subtype	None
		Infection duration	Positive
		Transmission mode	Weakly positive	Modestly higher bnAb activity in IDUs
		CD4+ T cell levels	Weakly positive	Contemporaneous; modest association with cross-neutralization activity
Sather et al. [49]	39	Viral load	Positive	Average of all tested time points
		Infection duration	Positive
		CD4+ T cell levels	None	Average of all tested time points
van Gils et al. [50]	35	Viral load	Positive	Set point
van Gils et al. [50]	35	CD4+ T cell levels	Negative	Set point

^aIndicates total number of subjects included. Specific analyses may have been carried out on subsets of these numbers

Back to article page

ISSN: 1742-4690

Contact us

Submission enquiries: journalsubmissions@springernature.com