Fig. 5

Remodeling of fibrils was monitored using ThT (a) or Congo red (b) assays. Mature SEVI fibrils were incubated with various concentrations of myricetin (500, 250, 125 μg/ml) or PBS and agitated as described above for 72 h. Aliquots were removed at the indicated time points. c–e At various time points (1 min, 24 and 48 h), the samples collected in the above-described remodeling experiment were measured by CD. Average values (± SD) were calculated from triplicate measurements; the data shown represent one representative trial of three independent experiments