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Fig. 4 | Retrovirology

Fig. 4

From: Cell surface ectodomain integrity of a subset of functional HIV-1 envelopes is dependent on a conserved hydrophilic domain containing region in their C-terminal tail

Fig. 4

Minimal CT region of 4-2.J41wt Env required for restoring native antigenicity/conformation. a Schematic representation of CHD deleted mutants of 4-2.J41 Env proteins. b FACS-based cell surface staining assay of CHD deleted mutants with the bNAb, VRCO1 and non-NAb, F105. c Binding of CHD deleted mutants to CD4bs-directed non-NAb, b6 and CD4i-directed non-NAb, 17b at 20 µg/ml concentration. The error bars indicate the standard mean obtained from two independent experiments run in duplicates (P < 0.0001)

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