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Fig. 1 | Retrovirology

Fig. 1

From: Cell surface ectodomain integrity of a subset of functional HIV-1 envelopes is dependent on a conserved hydrophilic domain containing region in their C-terminal tail

Fig. 1

CT-deleted 4-2.J41 Env has altered cell surface antigenicity/conformation. a Schematic of different domains in the C-terminal tail of HIV-1 Env. b FACS based cell surface staining assays of 4-2.J41WT and 4-2.J41ΔCT711 with cleavage non-specific bNAb, VRC01 and non-NAbs, F105, 17b and b6 over a range of antibody concentrations. c FACS based cell surface staining assays of 4-2.J41WT and 4-2.J41ΔCT711 with glycan-dependent, conformational bNAbs, PG9, PG16, PGT121, PGT128. d FACS based cell surface staining assays of 4-2.J41WT and 4-2.J41ΔCT711 with bNAb, VRC01 and trimer-selective, cleavage-specific bNAb, PGT151

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Retrovirology

ISSN: 1742-4690

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