Fig. 5

Summary of IUPM estimates obtained by a Bayesian analysis of experimental data from subjects 106 (high clonality) and 111 (low clonality). IUPM was estimated separately using sequence data obtained for HIV regions pol (red) and gp41 (blue, hatched). Three replicate chains were combined for each patient and gene after assessing that the chains had converged to the posterior distribution over the IUPM parameter. Median estimates are indicated by vertical line segments within each density plot. Grey bars represent the maximum likelihood estimate and 95% confidence interval obtained by IUPMStats [17]. In the case of patient 106, the upper confidence limit from IUPMStats extends to 35.6 cells per million