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Fig. 2 | Retrovirology

Fig. 2

From: Global phosphoproteomics of CCR5-tropic HIV-1 signaling reveals reprogramming of cellular protein production pathways and identifies p70-S6K1 and MK2 as HIV-responsive kinases required for optimal infection of CD4+ T cells

Fig. 2

Venn diagram displaying overlap across three HIV datasets. CCR5-HIV signaling refers to HIV-responsive phosphoproteins (responsive in either HIV or HIV + MVC groups compared to MV controls) described in this study. CXCR4-HIV are HIV-responsive peptides reported by Wojcechowskyj and colleagues and HHPID is the HIV-1 Human Protein Interaction Database. There is statistically significant overlap of members between a the CCR5-HIV dataset vs. CXCR4-HIV (p < 1 × 10−15, hypergeometric test) and b between CCR5-HIV and the HHPID (p < 1 × 10−15, hypergeometric test). Both tests were calculated against a background of 21,764 protein-coding genes from the GeneCards database, as of March 2017. c Overlap of proteins in the CCR5-HIV, CXCR4-HIV, and HHPID datasets

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Retrovirology

ISSN: 1742-4690

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