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Fig. 4 | Retrovirology

Fig. 4

From: HIV latency reversing agents act through Tat post translational modifications

Fig. 4

JQ1 affects alternative splicing by modulating hnRNP protein levels. Alternative splicing pattern of CD46 (a), ATF2 (b) and ABI1 (c) in HEK293T cells following 24 h of JQ1 (1 μM) or DMSO treatment. Inclusion and exclusion of exons are indicated on the right of the gel with white boxes, while grey boxes represent constitutively included exons. NTC = No Template Control, -RT corresponds to minus reverse transcriptase control. d Western Blot analysis of splicing factors following treatment with JQ1 or DMSO diluent control

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