Fig. 6
From: Efficacies of Cabotegravir and Bictegravir against drug-resistant HIV-1 integrase mutants
Antiviral activities of BIC and CAB against a panel of INSTI-resistant double mutants that included the primary mutations T66I and N155H with additional mutations at other positions. The EC50 values were determined using vectors that carry the INSTI-resistant double mutants in single round infection assays. Error bars represent the standard deviations in the data from independent experiments (n = 4). The EC50 values shown in the figure have a maximum of 100 nM. The EC50 values of RAL against this entire panel of INSTI-resistant double mutants were all > 100 nM. The EC50 values of EVG against E92Q/N155H and Y143R/N155H were all > 100 nM