Fig. 5
From: Efficacies of Cabotegravir and Bictegravir against drug-resistant HIV-1 integrase mutants
Antiviral activities of BIC and CAB against a panel of INSTI-resistant double mutants that have a primary mutation at position Q148. The EC50 values were determined using vectors that carry the INSTI-resistant double mutants in single round infection assays. Error bars represent the standard deviations in the data from independent experiments (n = 4). The EC50 values shown in the figure have a maximum of 100 nM. The EC50 values of RAL and EVG against this entire panel (except for EVG versus Y143R/Q148H) were all > 100 nM. The EC50 values of DTG against G140A/Q148K, CAB versus E138K/Q148K, G140A/Q148K, G140S/Q148R, and BIC against G140A/Q148K were all > 100 nM