Fig. 4
From: Efficacies of Cabotegravir and Bictegravir against drug-resistant HIV-1 integrase mutants
Antiviral activities of BIC and CAB against common INSTI-resistant single mutants. The EC50 values were determined using vectors that carry the INSTI-resistant IN double mutants in single round infection assays. Error bars represent the standard deviations in the data from independent experiments (n = 4). The EC50 values shown in the figure have a maximum of 100 nM. The EC50 values of RAL against Q148H, Q148K, and Q148R and EVG versus Q148K and Q148R INSTI-resistant mutants were all > 100 nM