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Fig. 10 | Retrovirology

Fig. 10

From: Efficacies of Cabotegravir and Bictegravir against drug-resistant HIV-1 integrase mutants

Fig. 10

Antiviral activities of CAB and BIC against a panel of INSTI-resistant triple mutants that include the well-characterized RAL-resistant double mutant G140S/Q148H plus an additional secondary mutation. The EC50 values were determined using vectors that carry the INSTI-resistant triple mutants in single round infection assays. Error bars represent the standard deviations in the data from independent experiments (n = 4). The EC50 values shown in the figure have a maximum of 100 nM. The EC50 values of RAL and EVG against this entire panel of INSTI-resistant triple mutants were all > 100 nM. The EC50 values of CAB against G140S/Y143R/Q148H and G140S/Q148H/N155H were all > 100 nM

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