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Table 3 Absence of PERV transmission in recent preclinical xenotransplantations

From: Why was PERV not transmitted during preclinical and clinical xenotransplantation trials and after inoculation of animals?

Donor pigs

Transplant

Recipient (number)

Immuno-suppression, encapsulation

PERV testing

References

PCR analysis

Antibody detection

Genetically modified large white × landrace or miniature swine

Heterotopic heart, kidney, thymokidney

Baboons (10)

Mycophenolate mofetil, FK506, anti-CD154mAb, anti-CD2mAb, steroids, radiation, anti-thymocyte globulin, cobra venom factor

Micro-chimerism

Nt

Issa et al. [78]

Genetically modified German landrace × large white

Orthotopic heart

Baboons (6)

Anti-CD20mAb, anti-CD40mAb, ATG, mycophenolate mofetil, methylprednisolone

Negative

Negative

Morozov et al. [79], Denner et al. unpublished

German landrace expressing INSLEA29Y

Islet cells

Marmosets (4)

None

Negative

Negative

Plotzki et al. [53]

Göttingen minipigs

Islet cells

Cynomolgus monkeys (8)

Macrodevice

Negative

Negative

Morozov et al. [80]

Large white × Yorkshire × landrace

Islet cells

Cynomolgus monkeys (6)

Agarose encapsulation

Negative

Nt

Gazda et al. [81]

  1. Only recent trials and only trials performing PERV testing. Seven other trials have been analysed previously [28]
  2. Nt not tested