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Table 2 PERV inoculation experiments into small animals and NHP

From: Why was PERV not transmitted during preclinical and clinical xenotransplantation trials and after inoculation of animals?

Recipient Virus source Immuno-suppression, treatment PERV testing References
PCR analysis Antibody detection
SCID micea Human cell-adapted PERV None Negative nt Irgang et al. [45]
  Transplantation of pig PBMCs None Negative nt Kuddus et al. [72]
Rats Supernatant PK-15 cells, supernatant PERV-infected 293 cells, human cell-adapted PERV Cyclosporine A, cobra venom factor Negative Negative Denner et al. [73]
Mink Supernatant PERV-infected 293 cells, human cell-adapted PERV None Negative Negative Specke et al. [39]
Guinea pigs Supernatant PK-15 cells, supernatant PERV-infected 293 cells None Negative Negative Specke et al. [44]
  PERV-NIH None Transient positive Positive Argaw et al. [71]
Rhesus monkeys, pig-tailed monkeys, baboons Human cell-adapted PERV Cyclosporine A, everolimus (RAD), methyl-prednisolone Negative Negative Specke et al. [41, 42]
  1. Nt not tested
  2. aReports showing that SCID mice were infected with PERV [74, 75] were the result of an artefact based on pseudotyping between PERV and endogenous murine retroviruses [76, 77]