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Table 2 PERV inoculation experiments into small animals and NHP

From: Why was PERV not transmitted during preclinical and clinical xenotransplantation trials and after inoculation of animals?

Recipient

Virus source

Immuno-suppression, treatment

PERV testing

References

PCR analysis

Antibody detection

SCID micea

Human cell-adapted PERV

None

Negative

nt

Irgang et al. [45]

 

Transplantation of pig PBMCs

None

Negative

nt

Kuddus et al. [72]

Rats

Supernatant PK-15 cells, supernatant PERV-infected 293 cells, human cell-adapted PERV

Cyclosporine A, cobra venom factor

Negative

Negative

Denner et al. [73]

Mink

Supernatant PERV-infected 293 cells, human cell-adapted PERV

None

Negative

Negative

Specke et al. [39]

Guinea pigs

Supernatant PK-15 cells, supernatant PERV-infected 293 cells

None

Negative

Negative

Specke et al. [44]

 

PERV-NIH

None

Transient positive

Positive

Argaw et al. [71]

Rhesus monkeys, pig-tailed monkeys, baboons

Human cell-adapted PERV

Cyclosporine A, everolimus (RAD), methyl-prednisolone

Negative

Negative

Specke et al. [41, 42]

  1. Nt not tested
  2. aReports showing that SCID mice were infected with PERV [74, 75] were the result of an artefact based on pseudotyping between PERV and endogenous murine retroviruses [76, 77]