Fig. 5

Early development of SIV Env gp120-directed plasma IgG ADCC and SIV-infected cell binding in AGMs. ADCC activity against the autologous challenge SIV envelope (Env) a gp140 and b gp120-coated cells of plasma IgG from SIVsab92018ivTF-infected AGMs and SIVmac251-infected RMs prior to infection, at week 6 (AGM) or 5 (RM), and 15 (AGM) or 17 (RM) was quantified as ADCC antibody titers. c Binding to SIV-infected cells was measured as % FITC positivity after week 0 background subtraction. d Plasma gp120-specific ADCC responses (median shown) after depletion with a linear V2 peptide or scrambled peptide in SIV-infected AGMs at week 6. e Neutralizing responses (median shown) in SIVsab92018ivTF-infected AGMs against the autologous challenge virus at week 15 after depletion with a linear V2 peptide and scrambled peptide