Fig. 3

Autologous and heterologous V1V2- and linear V2-specific plasma IgG binding responses in SIV-infected AGMs. Autologous SIVsab92018ivTF and SIVmac251 linear V2 peptides were tested by ELISA using plasma samples from a SIVsab92018ivTF-infected AGMs (n = 5 for 15 wpi, and n = 6 for all other time-points), and b SIVmac251-infected RMs (n = 3 for 5 wpi, and n = 4 for all other time-points) throughout infection. c Heterologous plasma linear V2-specific IgG binding in 6 SIVsab92018ivTF-infected AGMs was assessed against SIVsab92018WT, and SIVmac239 and HIV-1 Consensus subtype B (ConB) overlapping linear V2 peptides with (#) indicate peptide number, and the last four amino acids from each peptide. Cross-reactivity of AGM V1V2-specific plasma IgG binding was also tested using SIVsab92018ivTF, and SIVmac251 and HIV-1 ConB V1V2 proteins by ELISA. Shown are the median OD binding curves with range for all monkeys against Env specificity at each time-point