Table 1 Study groups, clinical outcomes, neuropathological and systemic pathological findings, and SIV infection in brain regions and systemic organs

SIV + CART−

Y

Y

A

Corticospinal tract microglial activation

–

–

–

–

–

–

Y

N

A+

Bronchopneumonia, mild; nephritis, mild

–

–

–

–

–

–

N

Y

B

SIV encephalomyelitis

+ 3.5 × 10⁵

+

+

+

+

+

N

Y

C−

Bacterial meningitis; rare SIV + cell in spinal cord

− 5.2 × 10¹

–

–

–

–

–

N

Y

C−

–

–

–

–

–

–

N

N

A−

CMV radiculitis; CMV meningoencephalitis; diffuse microglial activation WM > GM

CMV aspiration pneumonia

− 1.4 × 10⁰

–

–

–

–

–

Y

Y

F−

–

–

–

–

–

–

SIV-CART-

NA

Y

Y

A+

Nephritis, mild, focal

NA

Y

N

A+

NA

Y

Y

C

Medullary fibrosis

NA

Y

N

C−

NA

N

Y

D+

Global cortical contracted eosinophilic neurons

Splenic angiosarcoma; kidney angiosarcoma & hemorrhagic cyst; prominent macrophages in mes LNs, small bowel, & colon lamina propria

NA

N

N

B+

Benign liver cyst; pancreatic islet cells have cleared cytoplasm; inflamed coronary plaque; chronic inflammation of fallopian tubes; type II fiber atrophy in quadriceps muscles; interstitial inflammation in left kidney; metaplastic tubules in right kidney

SIV-CART+

NA

Y

N

A+

NA

Y

N

B

Diffuse myocardial fibrosis, mild

NA

Y

Y

C

Secondary demyelination in lateral column

NA

Y

N

D+

NA

Y

N

D+

Papillary muscle infarction, chronic

SIV + CART+

Y

N

A+

Chronic bronchitis, low level; macrophage infiltration of cardiac muscle, very mild

–

–

–

–

–

–

N

Y

B

SIV meningoencephalitis, mild; SIV + microglial nodules; SIV myelitis; vacuolar myelitis

Consolidating pneumonia (non-SIV-related), severe

+ 8.7 × 10²

+

+

+

+

Y

N

C+

Menigitis, mild, unknown etiology

− 3.7 × 10⁻¹

–

–

–

–

–

Y

Y

D+

PVCI

Alveolar macrophage infiltration, moderate, pigmented

–

R

–

–

–

–

Y

Y

F

Cerebellar infarct, chronic

Chronic inflammation of striated muscle adventitia

–

–

–

–

–

–

SIV + CART−

+

–

–

–

+

–

–

+

–

–

+

–

+

+

R

–

–

–

–

–

–

–

–

R

–

–

+

R

+

–

+

+

+

+

R

–

+

–

+

+

–

R

R

+

–

+

+

–

–

+

–

+

+

–

–

R

+

–

+

+

–

–

+

–

–

Peritracheal LN, adrenal gland

+

–

–

+

+

+

+

+

–

+

+

–

Peripheral nerves

–

–

–

–

–

–

+

–

–

–

–

–

–

SIV-CART−

SIV-CART+

SIV + CART+

–

–

–

–

–

–

–

–

–

–

–

–

–

+

R

+

–

+

–

+

+

–

+

+

–

–

+

–

R

–

–

–

–

+

–

–

+

–

–

+

–

–

–

–

–

+

–

–

–

–

–

–

–

–

–

–

–

+

–

–

–

+

–

–