Fig. 1
From: Structural alteration of DNA induced by viral protein R of HIV-1 triggers the DNA damage response
Vpr-induced structural alteration of DNA. a Representative AFM images of dsDNA and height profiles. Right panels depict height profiles detected in each cross section shown by white lines in the left panels. b rVpr decreased the Rq value. The experiments were repeated at least three times. Error bars indicate ± SEM. c RPA70 bound dsDNA after treatment of rVpr. RPA70 was pulled down using beads conjugated with DNA and detected by Western blotting (WB). d T4gp32 bound dsDNA after treatment with C45. T4gp32 was pulled down with DNA-bound beads in the presence of C45 or C45D18 peptide. Arrowhead, T4gp32