Table 1 Antiviral activity and toxicity of selected hits in multiple round MTT assay
From: Inhibitors of the integrase–transportin-SR2 interaction block HIV nuclear import
Class | Compound ID | IN–TRN-SR2 Pin at 50 µM (%)a | EC50 (µM)b | CC50 (µM)c | Protection (%)d | ||
|---|---|---|---|---|---|---|---|
3 | MVG001 | 65.3 | < | 8 | < | 8 | 2 |
MVG002 | 43.4 | > | 13 | = | 13 | 5 | |
MVG003 | 47.2 | > | 80 | = | 80 | 13 | |
MVG004 | 82.6 | > | 21 | = | 21 | 4 | |
MVG005 | 39.7 | > | 57 | = | 57 | 6 | |
MVG006 | 50.5 | > | 63 | = | 63 | 6 | |
MVG007 | 64.8 | > | 74 | = | 74 | 6 | |
MVG008 | 30.1 | > | 99 | = | 99 | 23 | |
MVG009 | 32.0 | > | 51 | = | 51 | 4 | |
6 | MVG010 | 37.1 | > | 100 | = | 100 | 6 |
MVG011 | 41.7 | > | 102 | = | 102 | 1 | |
MVG012 | 107.1 | > | 74 | = | 74 | 10 | |
MVG013 | 51.9 | > | 95 | = | 95 | 3 | |
MVG014 | 63.8 | > | 87 | = | 87 | 4 | |
MVG015 | 48.1 | > | 87 | = | 87 | 5 | |
MVG016 | 46.9 | > | 244 | > | 244 | 20 | |
MVG017 | < 10 | = | 195 | = | 229 | 52 | |
MVG018 | < 10 | > | 137 | > | 137 | 7 | |
MVG019 | < 10 | > | 250 | > | 250 | 6 | |
MVG020 | < 10 | > | 250 | > | 250 | 18 | |
MVG021 | < 10 | > | 250 | > | 250 | 34 | |
MVG022 | 44.9 | = | 67 | > | 136 | 53 | |
MVG023 | < 10 | > | 110 | > | 110 | 0 | |
MVG024 | < 10 | > | 36 | > | 45 | 49 | |
7 | MVG025 | 72.9 | > | 34 | = | 34 | 4 |
MVG026 | 45.7 | > | 35 | = | 48 | 4 | |
MVG027 | 43.2 | > | 57 | = | 57 | 6 | |
MVG028 | 58.7 | > | 56 | = | 80 | 13 | |
MVG029 | 48.8 | > | 57 | = | 57 | 3 | |
MVG030 | 71.6 | > | 97 | = | 97 | 25 | |
MVG031 | 62.3 | > | 53 | = | 53 | 4 | |
MVG032 | 46.5 | > | 48 | = | 48 | 5 | |
MVG033 | 49.5 | > | 59 | = | 59 | 20 | |
MVG034 | 43.0 | > | 73 | = | 73 | 16 | |
9 | MVG035 | 43.8 | > | 36 | = | 36 | 1 |
MVG036 | 105.6 | > | 55 | = | 65 | 46 | |
MVG037 | 43.1 | > | 85 | = | 85 | 22 | |
MVG038 | 47.2 | > | 59 | = | 59 | 0 | |
MVG039 | 40.1 | > | 17 | = | 17 | 1 | |
MVG040 | 43.6 | > | 25 | = | 25 | 25 | |
MVG041 | 54.0 | > | 35 | = | 35 | 2 | |
10 | MVG042 | 89.6 | > | 55 | = | 55 | 10 |
MVG043 | 102.0 | > | 67 | = | 67 | 4 | |
MVG044 | 75.9 | > | 250 | > | 250 | 22 | |
MVG045 | 11.4 | > | 203 | = | 203 | 21 | |
MVG046 | 10.3 | > | 207 | = | 207 | 32 | |
MVG047 | < 10 | > | 250 | > | 250 | 7 | |
MVG048 | < 10 | > | 87 | = | 87 | 0 | |
MVG049 | < 10 | = | 165 | > | 231 | 55 | |
MVG050 | 44.1 | > | 250 | > | 250 | 0 | |
MVG051 | < 10 | > | 250 | > | 250 | 22 | |
MVG052 | 20.1 | > | 66 | = | 66 | 8 | |
MVG053 | < 10 | > | 167 | > | 167 | 39 | |
MVG054 | 18.0 | > | 225 | = | 225 | 0 | |
MVG055 | < 10 | > | 167 | > | 167 | 21 | |
MVG056 | 71.1 | > | 250 | > | 250 | 24 | |
MVG057 | 23.3 | > | 250 | > | 250 | 16 | |
MVG058 | 53.7 | = | 170 | > | 250 | 24 | |