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Table 2 Profiling functional Fc effector functions

From: Systems serology: profiling vaccine induced humoral immunity against HIV

 

Effector

Complement activation

ADCP

ADCC

Antibody dependent Cytokine secretion

Antibody dependent Chemokine secretion

Antibody dependent Virus Inhibition

NK cells

−

−

+

+

+

+

Neutrophils

−

+

+

+

+

ND

Monocytes

−

+

+

+

+

+

Dendritic cells

−

+

−

+

+

ND

Complement

+

ND

ND

ND

ND

+

Examples of Assays

Complement assay

ELISA

Bead assay

Virion assay

Cr51 Release

RFADCC

GranToxiLux

Luciferase ADCC

BVADCC

ICS

ICS

ADCVI

References

[86, 108]

[10, 62, 63, 109,110,111]

[28, 112,113,114,115,116,117]

[31, 118]

[31]

[13]