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Table 2 Changes in nucleotide composition and total number of mutations for codon modification of regions 22-261 and 22-378 in gag

From: Increasing the CpG dinucleotide abundance in the HIV-1 genomic RNA inhibits viral replication

Construct

% A

% C

% G

% T

Total UpA

Total CpG

Total number mutations relative to wild type

WT 22-261

38

17

23

22

23

4

 

CM 22-261

18

36

32

15

3

22

80

CM 22-261lowCpG

24

27

34

15

5

4

59

CpG 22-261

32

25

22

21

19

22

21

WT 22-378

42

17

24

18

29

4

 

CM 22-378

22

35

32

12

3

30

109

CM 22-378lowCpG

28

26

33

13

7

4

79

CpG 22-378

36

25

22

17

23

30

30