From: Increasing the CpG dinucleotide abundance in the HIV-1 genomic RNA inhibits viral replication
Construct | % A | % C | % G | % T | Total UpA | Total CpG | Total number mutations relative to wild type |
---|---|---|---|---|---|---|---|
WT 22-261 | 38 | 17 | 23 | 22 | 23 | 4 | Â |
CM 22-261 | 18 | 36 | 32 | 15 | 3 | 22 | 80 |
CM 22-261lowCpG | 24 | 27 | 34 | 15 | 5 | 4 | 59 |
CpG 22-261 | 32 | 25 | 22 | 21 | 19 | 22 | 21 |
WT 22-378 | 42 | 17 | 24 | 18 | 29 | 4 | Â |
CM 22-378 | 22 | 35 | 32 | 12 | 3 | 30 | 109 |
CM 22-378lowCpG | 28 | 26 | 33 | 13 | 7 | 4 | 79 |
CpG 22-378 | 36 | 25 | 22 | 17 | 23 | 30 | 30 |