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Fig. 7 | Retrovirology

Fig. 7

From: Increasing the CpG dinucleotide abundance in the HIV-1 genomic RNA inhibits viral replication

Fig. 7

Decreasing the CpG abundance within HIV-1 CM22-261 and HIV-1 CM22-378 restores infectious virus production. HeLa cells were transfected with pHIV-1NL4-3, pHIV-1 CM22-261, pHIV-1 CM22-261lowCpG, pHIV-1 CM22-378 and pHIV-1 CM22-378lowCpG. The bar charts show the average of three independent experiments relative to HIV-1NL4-3. Error bars represent standard deviation. a, c The amount of infectious virus present in the media was measured in TZM-bl cells. b, d Virion production and intracellular Gag expression was measured using quantitative western blotting

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