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Fig. 7 | Retrovirology

Fig. 7

From: The HIV-1 integrase-LEDGF allosteric inhibitor MUT-A: resistance profile, impairment of virus maturation and infectivity but without influence on RNA packaging or virus immunoreactivity

Fig. 7

Secretion of IL-12, IFN-γ, IL2-R and MIP-1β induced by autologous MDDCs exposed to MUT-A-inactivated HIV-1. Cytokine and chemokine secretion in response to autologous MDDCs exposed to wt HIV-1 (NL4-3 DMSO) or MUT-A-inactivated HIV-1 (MUT-A 1 µM) in supernatants from a 6-day co-culture was assessed in duplicates by Luminex assay. Graph representing mean ± SD concentrations (pg/mL) of IL-12 (a), IFN-γ (b), IL2-R (c), and MIP-1β (d) analyzed after three different co-cultures

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