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Fig. 2 | Retrovirology

Fig. 2

From: The HIV-1 integrase-LEDGF allosteric inhibitor MUT-A: resistance profile, impairment of virus maturation and infectivity but without influence on RNA packaging or virus immunoreactivity

Fig. 2

Resistance profile of MUT-A. a Comparative resistance profile of MUT-A and references (EVG, BI-D and BI-224436). The color code subdivides the fold change in resistance into five levels of magnitude. b Long-term culture of infected MT4 cells with escalating concentrations of drugs. Cells were initially infected at 0.005 MOI with HIV-1 and were passaged twice weekly in the presence of RAL (filled circle), NVP (filled diamond), or MUT-A (filled upward triangle). The serial passage was carried out over 67 days. The highest concentration of compounds at which the virus could replicate in culture are shown. Error bars represent the variation obtained in one experiment done in triplicate. c Frequency of mutations in IN sequences. Cloned sequences were analyzed at day 23, 43 and 67 from 30 to 40 individual clones (% of total clones analyzed)

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