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Fig. 1 | Retrovirology

Fig. 1

From: The HIV-1 integrase-LEDGF allosteric inhibitor MUT-A: resistance profile, impairment of virus maturation and infectivity but without influence on RNA packaging or virus immunoreactivity

Fig. 1

Structure, biochemical and antiretroviral activities of MUT-A. a Chemical structure of MUT-A. b Titration of MUT-A ARV activity on HIV-1 NL4-3 and HxB2 strains in MT4 cell infection assay. c Biochemical activities of MUT-A on IN-LEDGF/p75 interaction (IC50) and of IN multimerization (activation concentration AC50 and maximum signal increase plateau). d EC50 of ARV activities of MUT-A and references HIV-1 NL4-3 and HxB2 strains in MT4 cell infection assay. DTG: INSTI Dolutegravir. e–g Correlations between IN multimerization (IN–IN) AC50 and IN-LEDGF/p75 IC50 (e), ARV EC50 and IN-LEDGF IC50 (f), ARV EC50s and IN–IN AC50s (g) of MUT-A compound series

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Retrovirology

ISSN: 1742-4690

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