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Table 1 ART EC50 (ng/ml) values in different myeloid cells and PBMCs compared to published CSF concentrations

From: Reduced antiretroviral drug efficacy and concentration in HIV-infected microglia contributes to viral persistence in brain

ART drug

PBMC EC50

BMDM EC50

HFM EC50

CSFa

AZT

2.1 ± 0.24

14.7 ± 1.2

27.0 ± 3.1

44.0 ± 6.0

RAL

1.1 ± 0.1

1.8 ± 0.2

3.3 ± 0.6

21.3 ± 5.0

ETR

0.64 ± 0.08

1.1 ± 0.25

3.6 ± 0.2

8.4 ± 1.1

DRV

1.2 ± 0.15

1.9 ± 0.3

8.1 ± 0.78

47.0 ± 8.8

MVC

2.67 ± 0.2

0.1 ± 0.02

1.0 ± 0.15

2.87 ± 0.4

DTG

0.77 ± 0.04

0.3 ± 0.13

0.59 ± 0.05

18

  1. aAll CSF concentrations are published data
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Retrovirology

ISSN: 1742-4690

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