Fig. 4From: Reduced antiretroviral drug efficacy and concentration in HIV-infected microglia contributes to viral persistence in brainIn vivo ART drug concentrations in brain, blood and liver. RAL and DRV were injected intraperitoneally into adult mice (1.2 mg/animal). ART drug concentrations were measured at 1 and 4 h post-drug administration in serum, liver and brain (cortex, striatum, cerebellum, medulla and hypothalamus). RAL was detected in all tissues at 1 h (a). At 4 h, b RAL levels were markedly reduced in serum and liver and not detected in brain. c DRV was detected in all tissues at 1 h but levels of DRV were also markedly reduced at 4 h (d). Results represent mean ± SEM (n = 4)Back to article page