Fig. 7
From: Cellular fatty acid synthase is required for late stages of HIV-1 replication
Potential mechanisms linking FASN activity to HIV-1 replication. (1) Provision of fatty acids used for ATP production and energy homeostasis, (2) creation of lipid micro domains (rafts) favoring HIV-1 budding, (3) generation of fatty-acyl adducts (e.g. palmitate or myristate) for post-translational modification (PTM) of Env, Gag, Nef, or host proteins, (4) homeostatic replenishment of membrane lipids lost during viral budding