Fig. 2

Distribution of α-helices and coiled-coil signals in representative Rev proteins of primate lentiviruses, a HIV-1, b HIV-2, and c SIV. Rev sequences, including accession numbers are ordered by groups, and HIV-1 group M is further ordered by clade, A–K. White arrows above all sequences indicate locations of the following Rev functional domains: N-terminal oligomerization domain (Oligo-1); C-terminal oligomerization domain (Oligo-2); RNA binding arginine rich motif (ARM); and nuclear export signal (NES). Residues in red indicate regions of predicted α-helices; residues in blue indicate predicted β-strand regions, and underlined residues represent regions of predicted coiled-coils. Sequences in the figure are a subset of the complete dataset in Additional file 2, which includes genome, Pol, and Env accession numbers for each sequence