HIV drug resistance against strand transfer integrase inhibitors

Retrovirology

Table 9 IN substitutions in viruses isolated from RAL- or EVG-experienced patients subsequently failing therapy with DTG

Previous INSTI	Baseline genotype	Genotype at DTG failure	References
RAL	G140S/Y143H/Q148H	L74I, M/E138A/G140S/Q148H	[43]
RAL	G140S/Q148H	L74M, I/T97A/G140S/Q148H	[43]
RAL	L74M/T97A/E138A/Y143R	L74M/T97A/E138A/Y143R/N155H	[43]
RAL	L74M/T97A/Y143R	L74M/T97A/Y143R/N155H	[43]
RAL	G140S/Q148H	T97A/E138K/G140S/Q148H/N155H	[43]
RAL	E138A/G140S/Q148H	E92Q/T97A/G140S/Q148H	[43]
RAL	G140S/Q148H	E138K/G140S/Q148H/N155H	[43]
RAL	E157Q	E157Q	[85]
RAL	G140S/Q148H/N155H	T97A/T112S/G140S/Q148H/N155H/S230N	[45]
RAL	S119R/S147G/V151I/N155H	A49P/L68F/T97A/S119R/E138K/S147G/V151I/N155H/L234V	[64]
RAL	ND^a	G118R	[34]
EVG	ND^a	G118R ^b	[34]

Substitutions that differ between baseline and treatment failure are in italics. Numbers refer to amino acid position in HIV integrase, one letter amino acid code used. Raltegravir (RAL), elvitegravir (EVG), dolutegravir (DTG), no change detectable (ND)
^aPatient had undetectable viral load when switched to DTG monotherapy
^bAlong with multiple polymorphisms in IN (D10E, E11D, S24D, D25E, N27H, V31I, L45Q, I60IM, V72IL, T112L, T124N, T125A, V126L, R127K, V201I, K215N, I220V, N232D, L234I and D286N)

ISSN: 1742-4690