Table 8 Levels of in vitro resistance for HIV-1 INSTI mutated viruses with non-canonical INSTI resistance pathways
From: HIV drug resistance against strand transfer integrase inhibitors
Genotype | RAL | EVG | DTG | CTG | BIC |
|---|---|---|---|---|---|
R263K | |||||
R263K | − | + | + | − | − |
M50I/R263K | − | + | + | NA | + |
M50I/S119R/R263K | + | ++ | + | NA | + |
H51Y/R263K | − | NA | + | NA | NA |
S119R/R263K | − | + | + | NA | + |
E138K/R263K | + | + | + | NA | NA |
S153Y/R263K | + | ++ | + | NA | + |
OTHER | |||||
M50I | − | − | − | NA | NA |
H51Y | − | NA | − | NA | NA |
H51Y/S147G | − | + | NA | NA | NA |
H51Y/R262K | − | NA | − | NA | NA |
V72I | NA | + | NA | NA | NA |
V72I/F121Y/T125K | ++ | ++ | − | + | NA |
V72I/F121Y/T125K/I151V | + | ++ | − | − | NA |
L74M/G118R | ++ | + | NA | NA | NA |
Q95K | + | + | NA | NA | NA |
T97A | − | − | − | NA | NA |
T97A/F121Y | +++ | +++ | − | NA | − |
L101I | − | NA | − | NA | NA |
L101I/S153F | − | − | − | NA | NA |
L101I/T124A/S153F | − | − | − | NA | NA |
H114Y | − | + | NA | NA | NA |
G118R | + | − | + | NA | NA |
G118R/E138K | + | − | + | NA | NA |
G118S | − | + | − | − | NA |
S119R | + | + | − | NA | + |
F121Y | ++ | ++ | + | − | − |
F121Y/T124A | + | + | NA | NA | NA |
F121Y/T125K | + | ++ | − | − | NA |
F121Y/G163R | NA | ++ | NA | NA | NA |
T124A | − | − | − | − | NA |
T124A/S153Y | − | + | NA | + | NA |
T125K | NA | − | NA | NA | NA |
A128T | − | − | NA | NA | |
E138K | − | − | − | NA | NA |
G140S | − | + | − | NA | NA |
P145S | − | +++ | − | − | NA |
Q146L | − | ++ | NA | + | NA |
Q146P | + | NA | NA | NA | |
Q146R | − | + | − | − | NA |
S147G | − | + | − | NA | NA |
V151I | + | NA | NA | NA | |
V151L | + | ++ | + | NA | NA |
S153F | − | + | − | NA | NA |
S153Y | − | + | + | NA | NA |
M154I | − | − | − | NA | NA |
E157Q | − | + | − | NA | NA |
G193E | − | − | − | NA | NA |
S230R | − | NA | − | NA | NA |