Table 5 Levels of in vitro resistance for HIV-1 INSTI mutated viruses with elvitegravir resistance pathways
From: HIV drug resistance against strand transfer integrase inhibitors
Genotype | RAL | EVG | DTG | CTG | BIC |
|---|---|---|---|---|---|
T66 | |||||
T66A | − | + | − | − | NA |
T66A/S153F | − | ++ | NA | NA | NA |
T66I | − | + | − | − | NA |
T66I/L74M | + | ++ | − | − | NA |
T66I/E92Q | ++ | +++ | − | − | NA |
T66I/F121Y | + | ++ | NA | NA | NA |
T66I/S153Y | − | +++ | NA | NA | NA |
T66I/E157Q | − | ++ | − | NA | − |
T66I/Q146P | NA | +++ | NA | NA | NA |
T66I/Q146P/S147G | NA | +++ | NA | NA | NA |
T66I/Q95K/Q146P/S147G | NA | +++ | NA | NA | NA |
T66I/Q95K/E138K/Q146P/S147G | NA | +++ | NA | NA | NA |
T66I/T97A/E157Q | − | ++ | − | NA | − |
T66I/R263K | − | ++ | − | NA | NA |
T66I/E138K/R263K | + | +++ | − | NA | NA |
T66K | + | +++ | − | − | NA |
T66K/L74M | ++ | +++ | + | + | NA |
E92 | |||||
E92G | − | + | − | NA | NA |
E92G/S153F | − | + | NA | NA | NA |
E92I | − | + | − | − | |
E92Q | + | ++ | − | − | − |
V72I/E92Q/E157Q | + | ++ | NA | NA | NA |
E92Q/S147G | − | + | NA | NA | NA |
H51Y/E92Q/S147G | NA | +++ | NA | NA | NA |
H51Y/E92Q/S147G/E157Q | NA | +++ | NA | NA | NA |
E92Q/E157Q | ++ | ++ | − | NA | − |
E92Q/R263K | + | +++ | − | NA | |
E92V | − | + | − | − | NA |