Table 2 In vitro and in vivo selection of de novo exclusively raltegravir-associated resistance substitutions in HIV IN in tissue culture and in INSTI-naïve individuals
From: HIV drug resistance against strand transfer integrase inhibitors
Substitutions | RAL | |
|---|---|---|
Selection | In vitro | In vivo |
Y143 | ||
Y143C | X | X |
L74M/T97A/Y143R/G163R | X | |
T97A/Y143C/G163R | X | |
Q95K/Y143C | X | |
L74M/T97A/E138D/Y143R/G163N | X | |
T97A/Y143C | X | |
Y143C/S230R | X | |
L74M/T97A/Y143G | X | |
Y143H | X | X |
Y143K | X | |
T97A/Y143S | X | |
T97A/E138A/Y143K | X | |
Y143S/V201I | X | |
Y143R | X | X |
V72I/Y143R/T206S | X | |
L74M/T97A/Y143R | X | |
L74M/T97A/E138A/Y143R | X | |
T97A/Y143R | X | |
Y143R/D232N | X | |
G140S/Y143R | X | |