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Fig. 2 | Retrovirology

Fig. 2

From: A conflict of interest: the evolutionary arms race between mammalian APOBEC3 and lentiviral Vif

Fig. 2

Evolution of mammals and their A3 genes. Left A phylogenetic tree of mammals associated with lentiviruses with the geologic time (top) and age (bottom) scales is shown [14, 125]. In the phylogenetic tree, a subclass (Eutheria), a clade (Boreoeutheria), a superorder (Afrotheria), and some major orders (Primates, Rodents, Carnivora, Perissodactyla, Cetartiodactyla, Chiroptera, and Marsupialia) are labeled on each branch. Representative animals are illustrated with their common names and scientific names (in parentheses). Middle Schematics of the A3 genes in each mammal are shown. The A3 genes encoded in the CBX6-CBX7 loci of respective mammals are summarized. The name of each A3 gene is indicated on each open reading frame. Z1, Z2 and Z3 domains, which are classified by amino acid sequence, are shown in green, yellow, and blue, respectively [4]. Note that A3 genes are not encoded in the genome of opossum [115]. The “?” indicates that the number and composition of A3 genes in these mammals are currently unknown. Right The exogenous lentivirus in each mammal is shown. ND not detected (yet)

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