Fig. 6
From: Molecular mechanisms by which HERV-K Gag interferes with HIV-1 Gag assembly and particle infectivity
HERV-K Gag reduces release efficiency of HIV-1 through inhibition of an early stage. HIV-1 mutants are defective for the HIV-1 assembly at the early stage. HeLa cells were cotransfected with indicated HIV-1 mutants and indicated pCRVI plasmids at 10:1 ratio. Two days later, the amount of p24 released into the supernatants was measured by ELISA. Data from three independent experiments are shown as means ± standard deviations. P values were determined using a Student’s t test. *P < 0.01; **P < 0.001; ***P < 0.0001; n.s. not significant